Ctcf and ctcfl in cancer

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August undefined, 2024

WebNov 15, 2013 · Estrogens play a key role in breast cancer, with 60-70% of the cases expressing estrogen receptors (ERs), which are encoded by the ESR1 gene. CTCFL, a paralogue of the chromatin organizer CTCF, is a potential biomarker of breast cancer, but its expression in this disease is currently controversial. A positive correlation has been … WebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although …

CTCF and CTCFL in cancer Request PDF - ResearchGate

WebAug 4, 2024 · Pancreatic cancer’s poor prognosis is caused by distal metastasis, which is associated with epigenetic changes. However, the role of the 3D epigenome in pancreatic cancer biology, especially its metastasis, remains unclear. ... Notably, all sets of NDRs had CTCF and CTCFL motifs, which was consistent with the fact that CTCF is a vital ... Web2 days ago · Cancer remains the main cause of human death worldwide, and most cancers still lack effective prevention and treatment means [].In recent years, immune checkpoint (ICP) blockade and targeted drug therapy have greatly improved the therapeutic effect of cancer patients, but there are still problems such as limited patient benefit and difficulty … how much is sky talk anytime extra

Pan-cancer analysis and experimental validation of DTL as a …

WebApr 1, 2024 · CTCF and CTCFL contain N-terminal and C-terminal domains and a central 11-zinc finger region. CTCF binds to approximately 80 000 sites on mammalian … WebApr 4, 2024 · CTCF provided by HGNC Official Full Name CCCTC-binding factor provided by HGNC Primary source HGNC:HGNC:13723 ... LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis. ... CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of … WebMay 4, 2024 · In recent years, the most extensively studied disease related to CTCF protein is cancer. Debaugny and Skok reviewed the oncogenic roles of CTCF and CTCFL (CTCF-like or BORIS; the paralog of CTCF, see below section for BORIS). Human IDH gene mutant gliomas exhibit DNA hypermethylation, which ... how much is sky sports on virgin media

3D chromatin architecture and transcription regulation in cancer

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WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only present in the testis. However, it is also aberrantly expressed in many cancers. While it is known that shared and unique zinc finger sequences in CTCF and CTCFL … http://www.cancerindex.org/geneweb/CTCFL.htm how much is sky sports f1WebFeb 1, 2014 · CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS. CTCF and BORIS can be deregulated in cancer. The tumour suppressor gene CTCF can be mutated or deleted in cancer, or CTCF DNA binding can be altered by epigenetic changes. BORIS is aberrantly expressed frequently in cancer, leading some … how much is sky superfast broadband

"WebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ... " - Ctcf and ctcfl in cancer

Ctcf and ctcfl in cancer

WebMar 29, 2024 · CTCF and CTCFL in cancer. Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress. Defining the relative and combined contribution … WebCancer; Cell Biology; Stem Cells & Development; Metabolic & Cardiovascular Disease; ... 我们为您找到 ctcf 的 1 个相关产品结果。 ... Synonyms: CTCFL;BORIS;CT27;CTCF-T;HMGB1L1;dJ579F20.2. Type: Rabbit Polyclonal Antibody (1) 加入对比（最多5 ...

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WebApr 10, 2024 · Pan-cancer bioinformatics analysis showed that the expression of DTL was correlated with the prognosis, immunotherapy, and clinical indexes in various cancers. ... NRF1, E2F4, STA T3, CTCF, CTCFL ... WebSep 15, 2024 · Specific CTCF binding events occur in human cancers. Cancer-specific CTCF binding can be induced by other transcription factors to regulate oncogenic gene …

WebNov 15, 2013 · Estrogens play a key role in breast cancer, with 60–70% of the cases expressing estrogen receptors (ERs), which are encoded by the ESR1 gene. CTCFL, a paralogue of the chromatin organizer CTCF, is a potential biomarker of breast cancer, but its expression in this disease is currently controversial. WebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although expression data have been contradictory . According to the TCGA data, CTCFL is mainly expressed in ovarian cancer (Supplementary Figure 2).

WebApr 13, 2024 · MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. April 13, 2024. MYC is a well characterized oncogenic transcription factor in prostate … WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is …

WebJun 15, 2005 · Abstract. CTCF is a candidate tumor suppressor gene encoding a multifunctional transcription factor. Surprisingly for a tumor suppressor, the levels of CTCF in breast cancer cell lines and tumors were found elevated compared with breast cell lines with finite life span and normal breast tissues. In this study, we aimed to investigate the …

how do i find my srn number for sharesWebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The … how do i find my spin code on the big spinWebApr 18, 2024 · In cancer, CTCF binding is disrupted through various mechanisms, such as DNA copy number alterations spanning domain boundaries 13, microdeletions within CBSs 13, and hypermethylation of CBSs 14 ... how do i find my ss amountWebOct 1, 2024 · Using the Kaplan Meier plotter the prognostic significance of mRNA levels of CTCFL in gastric, breast, and ovarian cancer were interrogated, similarly to the respective levels of CTCF. In gastric cancer high CTCFL mRNA expression levels are associated with worse OS compared with gastric cancers having low CTCFL mRNA expression (HR = … how much is sky tv a monthWebMar 30, 2024 · Here, we show that MYC reshapes the chromatin architecture of prostate cancer (PCa) cells through interacting with CTCF protein. By defining H3K27ac, AR and CTCF HiChIP profiles and CRISPR ... how much is sky tv going upWebCTCFL; Zinc finger protein CTCF-T; cancer/testis antigen 27; dJ579F20.2; Description CTCFL, a testis-specific DNA binding protein containing 11 C2H2-type zinc fingers, … how much is sky sports a monthWebFeb 16, 2024 · CTCF overexpression has been identified in breast cancer , cervical cancer , ovarian cancer , and hepatocellular carcinoma . Some mutations are related to tumors ( 15 ). In particular, hotspot binding site mutations occur at quite a high frequency (25%) in GC, and these mutations are associated with alterations in gene expression ( 16 ). how do i find my ssh private key